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TBXAS1 encodes a bifunctional enzyme that primarily converts PGH2 into thromboxane A2 (TXA2), a potent
vasoconstrictor and platelet activator. In parallel, it cleaves PGH2 into 12-hydroxyheptadecatrienoic acid
(12-HHT) and mutagenic malondialdehyde at equimolar ratios with TXA2. The enzyme additionally exhibits
dehydratase activity, metabolizing (15S)-HPETE into both 15-KETE and 15-HETE, demonstrating its versatile
role in eicosanoid metabolism spanning hemostasis, vascular tone regulation, and potential involvement in
oxidative stress pathways.
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