| GENE INFORMATION | ||
|---|---|---|
| Gene name | PTGES2 |
|
| Description | Prostaglandin E synthase 2 | |
| Gene type | Protein coding gene | |
| Chromosome | 9 | |
| Cytoband | q34.11 | |
| Chromosome location(bp) | 128120693 - 128128462 | |
| Ensembl | ENSG00000148334 | |
| UniProt | Q97Z7 | |
| PROTEIN FUNCTIONi |
|---|
| PTGES2 functions as an isomerase that converts PGH2 to PGE2 in vitro. However, its biological role and GSH dependence remain debated. In vivo, PTGES2 may form a complex with GSH and heme, potentially losing PGE2 synthesis activity. Instead, it might catalyze the degradation of PGH2 into 12(S)-hydroxyheptadecatrienoic acid (HHT) and malondialdehyde (MDA). |
NOTE: Gene expression values are scaled by log2(TPM+0.001).