| GENE INFORMATION | ||
|---|---|---|
| Gene name | GGT5 |
|
| Description | Gamma-glutamyltransferase 5 | |
| Gene type | Protein coding gene | |
| Chromosome | 22 | |
| Cytoband | q11.23 | |
| Chromosome location(bp) | 24219654 - 24245108 | |
| Ensembl | ENSG00000099998 | |
| UniProt | P36269 | |
| PROTEIN FUNCTIONi |
|---|
| GGT5 is a specialized enzyme that hydrolyzes the γ-glutamyl bond of glutathione and glutathione conjugates (e.g., leukotriene C4), but cannot cleave simple γ-glutamyl amino acids like γ-glutamyl leucine. Beyond hydrolysis, it mediates transpeptidation reactions to generate novel γ-glutamyl compounds. Importantly, GGT5 regulates immune responses by inactivating geranylgeranyl glutathione through γ-glutamyl group removal, highlighting its role in glutathione metabolism and immune modulation. |
NOTE: Gene expression values are scaled by log2(TPM+0.001).