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CYP4F2 is a cytochrome P450 monooxygenase that catalyzes the ω-hydroxylation of diverse endogenous
substrates. It primarily oxidizes long-chain and polyunsaturated fatty acids (PUFAs), converting arachidonic
acid to the vasoactive 20-HETE. The enzyme also inactivates key eicosanoids (e.g., LTB4, LXA4, HETEs) and
contributes to very long-chain fatty acid (VLCFA) degradation through successive ω-oxidation. Additionally, it
modulates vitamin metabolism by hydroxylating tocopherols (vitamin E) and inactivating phylloquinone (vitamin K1)
and menaquinone-4 (vitamin K2), thereby influencing their biological activity and retention.
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