| GENE INFORMATION | ||
|---|---|---|
| Gene name | CYP2U1 |
|
| Description | Cytochrome P450 family 2 subfamily U member 1 | |
| Gene type | Protein coding gene | |
| Chromosome | 4 | |
| Cytoband | q25 | |
| Chromosome location(bp) | 107931549 - 107953461 | |
| Ensembl | ENSG00000155016 | |
| UniProt | Q7Z449 | |
| PROTEIN FUNCTIONi |
|---|
| CYP2U1 is a cytochrome P450 monooxygenase that primarily catalyzes ω- and ω-1 hydroxylation of arachidonic acid and other long-chain fatty acids, modulating their signaling pathways. It also inactivates the endocannabinoid N-arachidonoyl-serotonin (an analgesic inhibitor of FAAH, TRPV1, and T-type calcium channels) via C-2 oxidation of its indole ring, generating a less active metabolite. This NADPH/O₂-dependent enzyme thus regulates both fatty acid metabolism and nociceptive signaling. |
NOTE: Gene expression values are scaled by log2(TPM+0.001).