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CYP2J2 is predominantly expressed in the cardiovascular system. It catalyzes NADPH/O₂-dependent
epoxidation of polyunsaturated fatty acids (PUFAs), converting arachidonic acid to vasoactive epoxyeicosatrienoic
acids (EpETrEs). Uniquely, it also exhibits NADPH/O₂-independent hydroperoxide isomerase activity, collaborating
with 15-lipoxygenase to transform hydroperoxyicosatetraenoates (HpETEs) into hydroxy epoxy metabolites (HEETs),
precursors of vasodilatory trihydroxyicosatrienoates (THETAs). Additionally, CYP2J2 metabolizes diverse xenobiotics
including drugs (e.g., amiodarone, tamoxifen) and anthelmintics (e.g., albendazole sulfoxidation), bridging roles in
cardiovascular eicosanoid signaling and xenobiotic clearance.
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