CYP2C8

GENE INFORMATION
Gene name	CYP2C8
Description	Cytochrome P450 family 2 subfamily C member 8
Gene type	Protein coding gene
Chromosome	10
Cytoband	p23.33
Chromosome location(bp)	95036772 - 95069497
Ensembl	ENSG00000138115
UniProt	P10632

PROTEIN FUNCTIONⁱ
CYP2C8 catalyzes NADPH/O₂-dependent oxidation of diverse endogenous and exogenous compounds. It primarily epoxidizes polyunsaturated fatty acids (preferentially at the terminal double bond) and hydroxylates carbon-hydrogen bonds in various substrates. Key endogenous activities include metabolizing all-trans-retinoic acid to 4-hydroxyretinoate and performing 16α-hydroxylation of estrogens (estradiol/estrone). It is notably the major enzyme for xenobiotic metabolism, serving as the principal catalyst for the biotransformation of the anticancer drug paclitaxel (taxol) and numerous other therapeutic agents.

PROTEIN FUNCTIONⁱ

CYP2C8 catalyzes NADPH/O₂-dependent oxidation of diverse endogenous and exogenous compounds. It primarily epoxidizes polyunsaturated fatty acids (preferentially at the terminal double bond) and hydroxylates carbon-hydrogen bonds in various substrates. Key endogenous activities include metabolizing all-trans-retinoic acid to 4-hydroxyretinoate and performing 16α-hydroxylation of estrogens (estradiol/estrone). It is notably the major enzyme for xenobiotic metabolism, serving as the principal catalyst for the biotransformation of the anticancer drug paclitaxel (taxol) and numerous other therapeutic agents.

CYP2C8

Boxplot

acknowledgement